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KMID : 0377519940190020151
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Chung-Ang Journal of Medicine
1994 Volume.19 No. 2 p.151 ~ p.160
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Effects of Mg2+ and MgATP on the Spontaneous Transient Outward Current in the Single Smooth Muscle Cells
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이상구
이무열/방효원/엄대용/이상돈
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Abstract
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Potassium channels are important in controlling membrane excitability and contractile activity in gastric antral smooth muscle. Many single channel recordings indicate that the large conductance Ca2+-activated K+channel is abundant in many smooth
muscle
cells. Spontaneous release of intracellular Ca2+ induces outward currents in some tissues. And they are thought to be produced by the activation of Ca2+-activated K+ channels. In this study, whole cell voltage clamp technique was used to examine
the
effects of Mg2+ and MgATP on spontaneous transient outward currents(STOCs). The following results were obtained.
1) STOCs were recorded in depolarized membrane potential ranges.
2) Increment of intracellular Ca2+ concentration increased the amplitude of STOCs.
3) Intracellular Mg2+ increased STOCs dose dependently.
4) MaATP also increased STOCs dose dependetly and the effects were more pronounced than other ATPs.
From the above results it can be suggested that the STOCs were affected by intracellular Mg2+ and MgATP.
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